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目的观察白细胞介素 6 (interleukin 6 ,IL 6 )及白细胞介素 6受体 (IL 6receptor,IL 6R)在胃正常粘膜、癌前病变、早期胃癌、进展期胃癌中的表达 ,探讨它们与胃癌发生发展的关系及临床意义。方法应用原位杂交技术检测 91例不同胃粘膜标本中IL 6及其受体mRNA表达情况 ,其中正常粘膜 2 0例 ,慢性萎缩性胃炎伴重度不典型增生和 (或 )肠上皮化生 2 0例 ,早期胃癌 2 5例 ,进展期胃癌 2 6例。结果IL 6mRNA在正常粘膜、癌前病变、早期胃癌、进展期胃癌中的阳性表达率分别为 10 %、5 5 %、84 %、84 .6 %。IL 6受体mRNA在胃粘膜不同病变中的阳性表达率分别为 10 %、5 0 %、80 %、88.4 %。IL 6及其受体mRNA在正常粘膜中的表达明显低于癌前病变 (P <0 .0 5 ) ;IL 6及其受体mRNA在癌前病变中的表达明显低于早期胃癌 (P <0 .0 5 ) ;而早期胃癌中的IL 6及其受体mRNA的表达与进展期胃癌无明显差异 (P >0 .0 5 )。结论IL 6及其受体与胃癌的发生发展有着密切关系
Objective To investigate the expression of interleukin 6 (IL 6) and interleukin 6 receptor (IL 6R) in normal gastric mucosa, precancerous lesion, early gastric cancer and advanced gastric cancer, and to explore their relationship with gastric cancer The relationship between development and clinical significance. Methods In situ hybridization was used to detect the mRNA expression of IL 6 and its receptor in 91 specimens of different gastric mucosa, including 20 normal mucosa, chronic atrophic gastritis with severe dysplasia and/or intestinal metaplasia 2 0 Cases, 25 cases of early gastric cancer, 26 cases of advanced gastric cancer. Results The positive rates of IL 6 mRNA in normal mucosa, precancerous lesions, early gastric cancer and advanced gastric cancer were 10%, 55%, 84%, and 84.6%, respectively. The positive expression rates of IL 6 receptor mRNA in different gastric lesions were 10%, 50%, 80%, and 88.4%, respectively. The expression of IL 6 and its receptor mRNA in normal mucosa was significantly lower than that in precancerous lesions (P < 0.05). The expression of IL 6 and its receptor mRNA in precancerous lesions was significantly lower than that in early gastric cancer (P < The expression of IL 6 and its receptor mRNA in early gastric cancer was not significantly different from that in advanced gastric cancer (P > 0.05). Conclusion IL 6 and its receptor are closely related to the occurrence and development of gastric cancer