论文部分内容阅读
目的探讨胆总管腺癌和癌旁组织中PUMA和ABCG2的表达水平及其临床病理意义。方法 40例胆总管腺癌和15例癌旁组织手术切除标本常规制作石蜡包埋切片,免疫组化法检测PUMA和ABCG2的表达。结果胆总管腺癌PUMA和ABCG2表达阳性率及其评分明显高于癌旁组织(PUMA:67.5%vs.13.3%,P=0.001,2.58±1.84vs.0.53±1.13,P=0.000;ABCG2:60.0%vs.13.3%,P=0.002,2.28±1.88vs.0.53±1.13,P=0.001)。PUMA和ABCG2表达阳性的癌旁组织上皮均呈轻至中度不典型增生;腺癌I级和淋巴结未转移病例PUMA和ABCG2表达阳性率及其评分明显低于腺癌II级或III级和淋巴结转移者(P<0.05或P<0.01)。PUMA和ABCG2在胆总管腺癌中表达评分呈高度正相关(r=0.65,P=0.000)。结论 PUMA和ABCG2表达与胆总管腺癌发生、临床生物学行为及预后有密切关系;两者的高表达预示预后不良。
Objective To investigate the expression of PUMA and ABCG2 in cholangiocarcinoma and adjacent tissues and their clinicopathological significance. Methods Forty cases of cholangiocarcinoma and 15 cases of para-carcinoma were paraffin-embedded sections and immunohistochemical methods were used to detect the expression of PUMA and ABCG2. Results The positive rates of PUMA and ABCG2 in cholangiocarcinoma were significantly higher than those in paracancerous tissues (PUMA: 67.5% vs.13.3%, P = 0.001,2.58 ± 1.84vs.0.53 ± 1.13, P = 0.000; ABCG2: 60.0 % vs.13.3%, P = 0.002, 2.28 ± 1.88 vs..0.53 ± 1.13, P = 0.001). The positive rates of PUMA and ABCG2 in patients with adenocarcinoma of grade I and non-metastatic lymph nodes were significantly lower than those of grade II or III adenocarcinoma and lymph nodes Metastasis (P <0.05 or P <0.01). PUMA and ABCG2 expression in cholangiocarcinoma was highly positive (r = 0.65, P = 0.000). Conclusions The expression of PUMA and ABCG2 is closely related to the occurrence of biliary adenocarcinoma, clinical biological behavior and prognosis. The high expression of both of them indicates the poor prognosis.