非那西丁和阿司匹林等解热镇痛药,在50年代初许多国家(澳大利亚、美、英等国)报道,这些药物可引起急性间质性肾炎(acute interstitial nephritis)。甚之这些病人最终出现可逆性肾功能衰竭,认为这与长期过量应用解热镇痛药有关而受到关注。实验研究获悉,其发病机理是与这类药的毒性代谢物有关。目前对解热镇痛药引起的急性间质性肾炎或肾乳头坏死,统称为镇痛药肾病(analgesic nephropathy)。一般认为有 Antipyretics and analgesics such as phenacetin and aspirin were reported in many countries in the early 1950s (Australia, the United States, Britain and other countries) and these drugs can cause acute interstitial nephritis. Even these patients eventually appear reversible renal failure, which is concerned with long-term excessive use of antipyretic analgesics and attention. Experimental study was informed that its pathogenesis is related to the toxic metabolites of these drugs. Currently on the antipyretic analgesics caused by acute interstitial nephritis or renal papillary necrosis, collectively referred to as analgesic nephropathy. Generally think there is