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目的掌握云南省华宁县健康人群乙型肝炎(乙肝)病毒感染状况及免疫水平,评价乙肝疫苗接种及纳入计划免疫的效果,为提高我县免疫规划工作提供科学依据。方法根据《全国人群乙肝等有关疾病血清学调查方案》的要求,结合华宁县具体情况,按容量比例概率抽样法(PPS)随机抽取769例健康人群,采用酶联免疫吸附试验(ELISA)检测乙肝表面抗原及抗体。结果调查的769例健康人群中乙肝疫苗接种率为77.11%,乙肝表面抗原阳性率为0.39%、乙肝表面抗体阳性率为75.81%,乙肝疫苗接种保护率为94.56%。不同乡镇、不同年龄组间乙肝疫苗接种率、乙肝表面抗体阳性率差异有统计学意义;性别间差异无统计学意义。结论华宁县健康人群乙肝疫苗接种保护率较高,乙肝疫苗免疫效果显著,还要加强重点人群的乙肝疫苗接种工作,巩固乙肝免疫效果。
Objective To understand the status and immunization status of hepatitis B virus (HBV) in healthy population of Huaying County of Yunnan Province, evaluate the effect of hepatitis B vaccination and planned immunization, and provide a scientific basis for improving immunization planning in our county. Methods A total of 769 healthy people were selected randomly according to the specific situation of Huaning County according to the National Serum Surveillance Program of Hepatitis B and Other Related Diseases in Nationwide Population. The levels of hepatitis B (HBV) were detected by enzyme-linked immunosorbent assay (ELISA) Surface antigens and antibodies. Results Among 769 healthy people surveyed, hepatitis B vaccination rate was 77.11%, hepatitis B surface antigen positive rate was 0.39%, hepatitis B surface antibody positive rate was 75.81% and hepatitis B vaccination rate was 94.56%. There were significant differences in hepatitis B vaccination rate and HBsAg positive rate in different townships and different age groups. There was no significant difference between the sexes. Conclusion Hepatitis B vaccination protection rate is high in healthy population of Huaning County. Hepatitis B vaccine has significant immunization effect. Hepatitis B vaccination should also be strengthened in key populations to strengthen the effect of hepatitis B vaccination.