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脑缺血再灌注时,缺血区有大量白细胞浸润。既往认为:缺血区白细胞的聚集浸润是继发于组织坏死的迟发的炎性反应,作用是清除梗死区坏死组织碎屑和参与疤痕形成;近年研究发现:白细胞不但在脑梗死的组织修复阶段起作用,而且脑缺血的早期即出现,在缺血再灌注损伤中发挥重要作用,使缺血向不可逆的梗死方向发展。白细胞到达缺血区是多步骤过程:附壁、与内皮细胞粘附、浸润到脑实质,每一步骤都受到细胞因子的调节。细胞因子是低分子量蛋白质,可由多种细胞产
Cerebral ischemia-reperfusion, the ischemic area has a large number of leukocyte infiltration. Previously believed that: the infiltration of ischemic leukocyte infiltration secondary to tissue necrosis is a delayed inflammatory reaction, the role is to clear necrotic tissue debris infarction and involved in scar formation; recent studies found that: leukocytes not only in tissue repair of cerebral infarction Stage play a role, and the early onset of cerebral ischemia that has an important role in ischemia-reperfusion injury, the ischemia to the irreversible infarction direction. Leukocytes reach the ischemic area is a multi-step process: attachment, adhesion with endothelial cells, infiltration into the brain parenchyma, each step by cytokine regulation. Cytokines are low molecular weight proteins that can be produced by a variety of cells