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作者用循环式血液灌注装置,发现呋喃二氢吡啶Ⅰ20μmol/L能使离体兔心局部缺血再灌损伤时,乳酸脱氢酶、谷草转氨酶释放量明显减少;心肌镁含量从对照的0.41±0.07mg/g干重组织升高到0.89±0.16mg/g干重组织(P<0.01,n=6),锌含量和心肌含水量分别从对照的0.09±0.02 mg/g干重组织和82.68％±0.84％下降到0.06±0.01mg/g干重组织和80.19％±0.99％(P均<0.01,n=6)。并预防缺血、再灌时心律失常的发生。说明:该药保护缺血心肌损伤与其对心肌组织镁、锌含量的影响有关。
The authors used a circular blood perfusion device and found that furan dihydropyridazine Ⅰ20μmol / L can cause isolated heart ischemia-reperfusion injury in rabbits, lactate dehydrogenase, aspartate aminotransferase release was significantly reduced; myocardial magnesium content from the control 0.41 ± 0.07mg / g dry weight tissue was increased to 0.89 ± 0.16mg / g dry weight tissue (P <0.01, n = 6), zinc content and myocardial water content were increased from 0.09 ± 0.02 mg / g dry weight tissue and 82.68 % ± 0.84% to 0.06 ± 0.01 mg / g dry weight and 80.19% ± 0.99% (all P <0.01, n = 6). And prevent ischemia, reperfusion arrhythmia. Description: The drug protection of ischemic myocardial injury and its impact on myocardial tissue magnesium, zinc content.