目的　建立恶性疟原虫免疫抑制多次部分换血猕猴模型。方法　应用免疫抑制剂抑制动物体内的溶血反应 ,采用多次部分换血的方法。结果　在此模型中 ,恶性疟原虫分别在猕猴体内存活 2 1天以上 ;最高感染率分别为 8 6 %、10 6 %和 6 4%。在应用此模型进行的抗疟药杀虫试验中 ,猴服用蒿甲醚 4h后 ,原虫感染率由 4 6 %迅速下降到 0 5 % ;2 4h后 ,原虫消失。结论　恶性疟原虫可以在免疫抑制的多次部分换血猕猴模型中较好地生长发育。此模型可以适用于部分原虫红内期的研究和抗疟药的药效实验 Objective To establish an immunosuppressive model of Plasmodium falciparum multiple partial transfusion with macaque. Methods Immunosuppressants were used to inhibit the hemolytic reaction in animals and the blood transfusion method was used several times. Results In this model, Plasmodium falciparum survived more than 21 days in rhesus monkeys, with the highest infection rates of 86%, 106% and 64%, respectively. In the antimalarial insecticide test using this model, the infection rate of protozoa dropped rapidly from 46% to 0 5% after 4 hours of administration of artemether in monkeys. After 24 hours, the protozoa disappeared. Conclusion Plasmodium falciparum can grow and develop well in the immunosuppressed multi-part transfusion rhesus macaque model. This model can be applied to the study of some protozoa erythrocytes and the efficacy test of antimalarial drugs