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药理研究 Midazolam(MZ)的药理性能与安定十分相似,但其作用时间较短。 1.抗惊厥作用:口服 MZ对 3-巯基丙酸(49 mg/kg)、戊四唑(120 mg/kg)以及电休克(50Hz,0.2s,10mA)所致小鼠惊厥均有保护作用。对于作用高峰期抗惊厥作用的ED_(50)与安定相近,但作用时间明显地较安定及其它苯二氮(艹卓)类为短。 2.对强制性运动和自发性运动的抑制作用:小鼠的转棒试验和烟囱试验,表明MZ抑制强制性运动的效价约为安定的4倍;光
Pharmacological studies Midazolam (MZ) pharmacological properties and stability is very similar, but its role in a short time. 1. Anticonvulsant effect: Oral MZ had protective effects on seizures in mice induced by 3-mercaptopropionic acid (49 mg / kg), pentylenetetrazole (120 mg / kg) and electrical shock (50 Hz, 0.2 s, 10 mA) . For the peak effect of anticonvulsant ED50 (50) and stability similar, but the action time was significantly more stable and other benzodiazepines (艹 Zhuo) class is shorter. 2. Forced exercise and spontaneous exercise inhibition: mouse stick test and the chimney test showed that the inhibitory effect of MZ forcing exercise is about 4 times the stability of the light; light