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宫腔粘连（ IUA）主要是由子宫内膜受损所致，可致不孕及流产等。近年来，由于宫腔操作增加以及对IUA认识和诊断水平提高，IUA发病率逐年上升。因其手术风险大，复发率高，预防再粘连手段有限，严重威胁育龄期女性身心健康。现有治疗对子宫内膜生理功能修复并不理想，内膜修复障碍可能是IUA发生的主要机制。目前对IUA内膜修复机制的认识十分有限，如果能破解IUA发病机制，或许可为IUA防治提供思路。“,”Intrauterine adhesion ( IUA) occurs mainly as a result of injury to endometrium ,in which may cause conditions such as infertility or abortion .In recent years,the incidence of IUA has been increasing year by year because of the increase of the uterine cavity operation and the improvement of the knowledge level and diagnosis of IUA.Because of the high risk of operation,high recurrence rate and limited prevention for re-adhesion,it is a serious threat to physical and mental health of women at childbearing age.Existing treat-ment is not ideal for the repair of endometrial physiology function .The disorder of endometrial repair may be the main mechanism of IUA.At present,the understanding of the mechanism of IUA endometrial repair is very limited,if the pathogenesis of IUA can be figured out,it may provide ideas for the prevention and treat-ment of IUA.