恶性疟原虫对氯喹的抗药性问题,是当前疟疾防治工作中急需弄清和亟待解决的重要问题。1974年,海南区寄生虫病防治研究所等在崖县、乐东县某些使用氯喹疗效不够满意的地方,按照世界卫生组织(1967)介绍的氯喹敏感性临床试验方法,对67例恶性疟患者观察结果,发现1例有抗药性。1975年6～11月,再组织有关单位,对海南岛西南部乐东县千家地区进行调查研究。现将资料整理报告如下。 The resistance of Plasmodium falciparum to chloroquine is an important issue urgently needed to be solved urgently in the current malaria prevention and control work. In 1974, Hainan Institute of Parasitic Diseases and other Clifford County, Ledong some use of chloroquine curative effect is not satisfactory enough place, according to the World Health Organization (1967) introduced chloroquine sensitive clinical trial methods, 67 cases of falciparum malaria Patients observed the results and found that 1 case of drug resistance. From June to November 1975, the relevant units were then organized to conduct a survey on thousands of areas in Ledong County in southwestern Hainan Island. The data is now summarized as follows.