We established an integrated and optimized model of vehicle scheduling problem and vehicle filling problem for solving an extremely complex delivery mode-multi-type vehicles, non-full loads, pickup and delivery in logistics and delivery system. The integrated and optimized model is based on our previous research result-effective space method. An integrated algorithm suitable for the integrated and optimized model was proposed and corresponding computer programs were designed to solve practical problems. The results indicates the programs can work out optimized delivery routes and concrete loading projects. The model and algorithm have many virtues and are valuable in practice.