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目的分析胎儿超声软指标与染色体异常的相关性,探究超声检查在胎儿染色体异常的筛查中的临床价值。方法选取河北省邯郸市中国人民解放军第285医院近5年来早中孕期(11~28周)检查提示胎儿超声软指标阳性的病例178例均接受胎儿染色体核型检查,对异常染色体核型的检出结果进行统计分析。结果 178例胎儿中染色体异常19例,其中不良结局的染色体核型共11例(非整倍体9例,结构异常2例),多个软指标阳性染色体异常的发生率为42.11%,显著高于单个软指标阳性的6.92%,差异有统计学意义(P<0.01)。结论对于多个超声软指标阳性的孕妇,建议行介入进一步明确诊断,对于单个软指标阳性的病例,应结合孕妇年龄等其他因素进行评估,减少介入性检查。
Objective To analyze the correlation between fetal soft index and chromosomal abnormalities and explore the clinical value of ultrasonography in the screening of fetal chromosomal abnormalities. Methods A total of 178 cases with positive fetal soft-sensor fetuses from 178th Hospital of Handan, People’s Liberation Army, Handan, Hebei Province during the first trimester of pregnancy (11-28 weeks) were enrolled in this study. Fetal chromosomal karyotype examination was performed in 178 cases of abnormal chromosome karyotype The results of statistical analysis. Results In 178 fetuses, there were 19 chromosomal abnormalities, of which 11 were chromosomal abnormalities (aneuploidy in 9 and structural abnormalities in 2). The incidence of multiple soft-index positive chromosomal abnormalities was significantly higher The single soft index positive 6.92%, the difference was statistically significant (P <0.01). Conclusions For multiple pregnant women with positive ultrasound soft indices, it is suggested that the intervention should be further involved in further diagnosis. For cases with positive single soft index, other factors such as the age of pregnant women should be evaluated to reduce the interventional examination.