支气管哮喘的发病机制虽有大量研究,但至今未完全阐明,近年来分子量在300～5000道尔顿之间的中分子物质(middlemolecular substances,MMS)在哮喘发病中的作用已有陆续报道,但它们之间的进一步关系却研究甚少。本文通过测定哮喘豚鼠血浆中MMS和环核苷酸水平,分析它们的相关性,应用SephadexG—15凝胶层析技术豚鼠血浆进行组分分析,探讨MMS是否参与哮喘的发病。 Although a large number of studies have been made on the pathogenesis of bronchial asthma, it has not yet been completely elucidated that the role of middlemolecular substances (MMS) with molecular weights of 300-5,000 Daltons in the pathogenesis of asthma has been reported in recent years Little research has been done on the further relationship between them. In this paper, we measured the levels of MMS and cyclic nucleotide in the plasma of asthmatic guinea pigs, and analyzed their correlations. We analyzed the plasma composition of guinea pigs by Sephadex G-15 gel chromatography to explore whether MMS is involved in the pathogenesis of asthma.