14例夜间哮喘患者(女8例),平均年龄50(30～63)岁,采用双盲试验法检测夜间1次大剂量服用慢释放间羟舒喘宁(简称慢释剂)对其肺功能和血气的影响。受试者无肺心病,近1个月内无呼吸道感染,吸入两剂间羟舒喘宁后呼气峰速(PEF)上升>15%。试验分3期,每期8天。第1期每日早晚各测PEF 1次,除不用慢释剂外,仍继续给常用药,如 14 patients with nocturnal asthma (8 females), average age 50 (30 ~ 63) years old, the use of double-blind test for the detection of a large dose of slow release of a small dose of oxychosudine (referred to as slow release agent) And blood gas effects. The subjects had no pulmonary heart disease and had no respiratory infection in the recent 1 month. The peak expiratory flow (PEF) increased by> 15% after inhaling two doses of oxytocin. The experiment is divided into 3 phases, each period is 8 days. The first day of each test PEF 1 times a day, except without slow release agent, still continue to commonly used drugs, such as