One Stone Two Birds—Enantioselective Bimetallic Catalysis for α-Amino Acid Derivatives with an Allen

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Main observation and conclusionrnA highly enantioselective 2,3-allenylation of acyclic and cyclic α-imino carboxylates via a synergistic bimetallic Pd/Cu catalysis with the same commercially available (R,Rp)-iPr-FOXAP (also as Phosferrox,(R,R)-[2-(4\'-i-propyloxazolin-2\'-yl)ferrocenyl]diphenyl phosphine)ligand for both metals affording optically active 2,3-butadienyl α-amino acid derivatives in high to excellent yields with excellent en-antioselectivities has been developed.
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