Balanced reciprocal translocation is one of the most common chromosome abnormalities,with an incidence of approximately 1 in every 500 newborns (Mackie Ogilvie and Scriven,2002).Most balanced reciprocal translocation carriers have no observable phenotype because there is no loss or gain of genetic material(Ogilvie et al.,2001).However,the carriers have a risk of infertility,recurrent miscarriage,or delivery of phenotypically abnormal offspring with mental retardation or other congenital abnormal-ities due to complex segregation modes during meiosis(Suzumori and Sugiura-Ogasawara,2010).Approximately 6％ of the carriers are associated with congenital malformations and/or developmental delay,which may be caused by the disruption of gene structure due to the breakpoints of translocation(Warburton,1991;lmaizumi et al.,2002;Vandeweyer and Kooy,2009).