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本文进行了两组不同剂量的阿芬太尼在14例手术病人中的药代动力学研究。7例病人一次性iv 80μg·kg~(-1)阿芬太尼,另7例手术病人一次性iv 40μg·kg~(-1)。用RIA法测定0-8 h 阿芬太尼的血浆浓度和0-48 h尿中阿芬太尼的回收率。研究结果表明,阿芬太尼在两组病人体内的药代动力学过程均为开放型三室模型。阿芬太尼的初级消除很快,给药后30 min内80%的原型药被消除。两组中的平均t_(1/2)在三相中无显著差异。主要药代动力学参数如下:
In this paper, two groups of different doses of alfentanil in 14 cases of surgical patients in the pharmacokinetic study. Seven patients were given iv 80μg · kg ~ (-1) alfentanil once, and the other seven patients were treated with iv 40μg · kg ~ (-1) once. The plasma concentration of alfentanil 0-8 h and the recovery of alfentanil in 0-48 h urine were determined by RIA. The results showed that the pharmacokinetics of alfentanil in both groups were open three-compartment model. The primary elimination of alfentanil is rapid and 80% of the prototype drug is eliminated within 30 min of administration. The mean t_ (1/2) in both groups showed no significant difference in the three phases. The main pharmacokinetic parameters are as follows: