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目的:观察腹部开放伤伴随不同温度海水浸泡条件下对大鼠生存时间及其伤情进展的影响。方法:建立腹部开放伤大鼠模型,健康雄性Wistar大鼠随机分为单纯腹部开放伤组和腹部开放伤伴随生理盐水或海水浸泡组。与单纯腹部开放伤相比,观察腹部开放伤合并10℃、15℃、22℃、26℃和33℃不同温度生理盐水或海水浸泡条件下大鼠的生存时间。结果:在相同温度下,与单纯腹部开放伤或腹部开放伤合并生理盐水浸泡组相比,腹部开放伤伴随海水浸泡大鼠生存时间明显缩短;与单纯腹部开放伤相比,腹部开放伤伴随10℃生理盐水浸泡大鼠生存时间明显缩短,而腹部开放伤伴随15℃、22℃、26℃和33℃生理盐水浸泡组大鼠生存时间没有显著差异;腹部开放伤合并海水浸泡条件下,大鼠在10℃、26℃和33℃水温浸泡较在15℃和22℃水温浸泡条件下生存时间明显缩短。结论:海水浸泡是加速腹部开放伤大鼠致死的重要因素之一。伴随过度低温(10℃)或接近体温(33℃)的海水浸泡都可加速腹部开放伤大鼠死亡。
OBJECTIVE: To observe the effects of open abdomen injury on the survival time and injury progression of rats under different seawater immersion conditions. Methods: A rat model of abdominal open injury was established. Healthy male Wistar rats were randomly divided into open abdominal injury group and open abdominal wound with saline or seawater immersion group. Compared with simple abdominal open injury, the survival time of rats under open abdominal injury with saline or seawater immersion at different temperatures of 10 ℃, 15 ℃, 22 ℃, 26 ℃ and 33 ℃ were observed. Results: At the same temperature, the survival time of open abdominal wound with seawater immersion was significantly shorter than that with open abdominal wound or abdominal open wound combined with saline immersion group. Compared with simple abdominal open wound, open abdominal wound accompanied with 10 ℃ physiological saline immersion rats survival time was significantly shortened, while open abdominal injury accompanied by 15 ℃, 22 ℃, 26 ℃ and 33 ℃ physiological saline immersion group rats had no significant difference in survival time; abdominal open wounds and seawater immersion conditions, rats The survival time at 10 ℃, 26 ℃ and 33 ℃ was significantly shorter than that at 15 ℃ and 22 ℃. Conclusion: Seawater immersion is one of the important factors in accelerating the lethality of open abdominal wound in rats. The seawater immersion with over-low temperature (10 ℃) or near body temperature (33 ℃) accelerated the death of rats with open abdominal wounds.