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自1976年以来,已有40多例败血症是由一种生长缓慢的革兰氏阴性杆菌,即生长不良酵母菌-2型(DF-2)所致。此种DF-2最近被命名为犬咬嗜吞噬细胞菌(Capnocytophaga Canimorsus)。DF-2感染常发生于狗咬伤或与狗(偶尔与猫)密切接触以后。其临床表现为蜂窝织炎、心内膜炎及脑膜炎。免疫能力受损的脾切除术或基础疾病可增加对感染的易感性,并可导致暴发性脓毒血症与播散性血管内凝血。DF-2在体外对所有抗生素(除噻肟单酰胺菌素外)均敏感。据报道,不用抗生素治疗,感染也可完全恢复,这可能与宿主抵抗力强或DF-2的毒力较小有关。
More than 40 sepsis cases have been reported since 1976 by a slow-growing Gram-negative bacterium, poor growth yeast-2 (DF-2). This DF-2 was recently named Capnocytophaga Canimorsus. DF-2 infection often occurs after a dog bites or intimate contact with a dog (occasionally with a cat). The clinical manifestations of cellulitis, endocarditis and meningitis. Splenectomy or underlying disease with impaired immunity can increase susceptibility to infection and can result in fulminant sepsis and disseminated intravascular coagulation. DF-2 is sensitive to all antibiotics (except thiazamicin) in vitro. It has been reported that infection can also be completely recovered without antibiotic treatment, which may be related to host resistance or to less virulence of DF-2.