系统性红斑性狼疮(SLE),硬皮病和皮肌炎,目前认为属于一组自身免疫性结缔组织病,各有其不同的临床表现和实验室特征。近年来发现有少数病例,常常同时出现这三种疾病的某些不典型症状的互相混杂,或兼有三种疾病症状者,1972年Sharp首先报导一组具有SLE、硬皮病和皮肌炎混合临床表现的病例,有区別于上述三种疾病所特有的临床表现和免疫学特征,命名为混合结缔组织病(Mixed SLE, scleroderma and dermatomyositis are currently considered to belong to a group of autoimmune connective tissue diseases, each with its own distinct clinical and laboratory characteristics. In recent years, a small number of cases were found, often accompanied by some atypical symptoms of these three diseases mixed with each other, or both symptoms of the disease, Sharp first reported in 1972 with a group of SLE, scleroderma and dermatomyositis mixed Cases of clinical manifestations, there are different from the three specific clinical manifestations of the disease and immunological features, named mixed connective tissue disease (Mixed