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作者研究了孕妇在妊娠期间服用苯并二氮(艹卓)类(BZD)药物对胎儿所产生的影响,结果发现,在孕期过度期用BZD 药物的孕妇所生婴儿,常存在面部畸形和中枢神经系统功能的严重紊乱。应警惕BZD 药物的致畸作用。方法作者对8例被怀疑因在妊娠期间服用大量BZD 药物而产出同样面部畸形及中枢神经系统机能障碍婴儿的母亲进行了调查。通过询问病史和查询医疗记录发现,5例在整个妊娠期间每日服用BZD 药物的剂量相当于去甲基羟安定(OZP)75mg 或安定(DZP)30mg,甚至更多。其中1例每日服OZP量达105mg,在妊娠的最后4周内改服甲硫哒嗪每日75mg。其中3例否认在孕期服用过任何药物,于
The authors studied the effect of pregnant women taking a benzodiazepine (BZD) drug on the fetus during pregnancy and found that infants born to pregnant women who used BZD drugs during pregnancy were often associated with facial deformities and central Serious disturbance of nervous system function. Be wary of teratogenic effects of BZD drugs. Methods The authors investigated 8 mothers of infants suspected of having the same facial deformity and central nervous system dysfunction due to taking a large amount of BZD medication during pregnancy. By inquiring about the medical history and consulting the medical records, it was found that the 5 daily doses of BZD medication equivalent to 75 mg of noroxyzacol (OZP) or 30 mg of diazepam (DZP) throughout the pregnancy were even more. One case of OZP serving daily dose of 105mg, in the last 4 weeks of pregnancy to change serotonazine daily 75mg. Three of them denied having taken any medication during pregnancy