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目的比较米非司酮联合妈富隆与单纯应用米非司酮治疗功能性子宫出血的疗效。方法将128例功能性子宫出血患者随机分入对照组与观察组,给予62例对照组患者口服米非司酮治疗,给予66例观察组患者米非司酮联合妈富隆治疗。比较两组临床疗效、黄体生成素(LH)、促卵泡素(FSH)和雌激素(E2)水平。结果观察组治疗总有效率显著高于对照组(100.0%vs 90.3%,P<0.05);观察组控制出血时间及完全止血时间显著少于对照组(P<0.05);与对照组相比,观察组治疗后血清FSH水平显著下降(P<0.05);两组血清LH及E2水平无显著差别(P>0.05)。结论米非司酮联合妈富隆治疗功能性子宫出血可提高临床疗效,且不良反应少。
Objective To compare the efficacy of mifepristone combined with marvelon and mifepristone in the treatment of functional uterine bleeding. Methods 128 patients with functional uterine bleeding were randomly divided into control group and observation group, 62 patients in the control group were treated with mifepristone, and 66 patients in the observation group were treated with mifepristone combined with Marvelon. The clinical efficacy, the levels of LH, FSH and E2 were compared between the two groups. Results The total effective rate in the observation group was significantly higher than that in the control group (100.0% vs 90.3%, P <0.05). The bleeding time and complete hemostasis time in the observation group were significantly less than those in the control group (P <0.05) The level of serum FSH in the observation group decreased significantly (P <0.05). There was no significant difference between the two groups in serum LH and E2 levels (P> 0.05). Conclusion Mifepristone combined with Marvelon treatment of functional uterine bleeding can improve the clinical efficacy, and fewer adverse reactions.