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目的评价血清Smith抗体(抗Sm)、抗核小体抗体(AnuA)、抗双链DNA抗体(抗dsDNA)、抗核糖体P蛋白(抗rRNP抗体)、抗核抗体(ANA)联合检测在系统性红斑狼疮(SLE)诊断中的临床应用价值。方法抗Sm、AnuA、抗rRNP抗体采用LIA法,抗dsDNA、ANA采用IIF法。结果 62例SLE患者抗Sm、AnuA、抗dsDNA、抗rRNP抗体和ANA阳性率分别是34%、61%、55%、19%、98%,五种自身抗体联合监测的阳性率为100%。结论自身抗体联合检测大大提高了SLE诊断的敏感性和特异性。
Objective To evaluate the diagnostic value of anti-Sm, anti-AuA, anti-dsDNA, anti-ribosomal P (anti-rRNP) and antinuclear antibodies (ANA) Clinical Application of SLE Diagnosis. Methods anti-Sm, AnuA, anti-rRNP antibody using LIA method, anti-dsDNA, ANA using IIF method. Results The positive rates of anti-Sm, AnuA, anti-dsDNA, anti-rRNP and ANA were 34%, 61%, 55%, 19% and 98% respectively in 62 SLE patients. The positive rate of the five autoantibodies was 100%. Conclusion The combined detection of autoantibodies greatly improves the sensitivity and specificity of SLE diagnosis.