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目的:探讨血清肝细胞生成因子(HGF)对急性心肌梗死(AMI)后早期左室重构的预测价值。方法:36例AMI患者入院时及发病7 d测定血清HGF水平;AMI其中的26例分别于发病后7～10 d及发病后3个月行超声心动图检查,3个月时左室舒张末期容积指数(LVEDVI)与7～10 d时比增加≥5 ml/m2定义为左室重构组(n=11),对两组血清HGF值进行比较。结果:AMI患者入院时血清HGF浓度较对照组明显升高[(809±288)ng/Lvs.(620±162)ng/L,P<0.01],7 d时升高更显著[(1 607±1 355)ng/L,P<0.01]。发病7 d时血清HGF浓度在左室重构组较非左室重构组升高[(2 216±1 522)ng/Lvs.(1 176±593)ng/L,P<0.05],而入院时两组浓度则无显著差异。结论:AMI时血清HGF浓度升高,AMI后7 d时增高的血清HGF可能预示心室重构。
Objective: To investigate the predictive value of serum hepatocyte growth factor (HGF) on early left ventricular remodeling after acute myocardial infarction (AMI). Methods: Thirty-six patients with AMI were admitted to hospital and the serum HGF levels were measured at 7 days after onset. Twenty-six of the AMI patients underwent echocardiography at 7-10 days and 3 months after onset respectively. Left ventricular end- Volumetric index (LVEDVI) and 7 ~ 10 d increased ≥ 5 ml / m2 defined as left ventricular remodeling group (n = 11), the serum HGF values were compared. Results: Serum HGF concentration at AMI was significantly higher than that of the control group [(809 ± 288) ng / L vs (620 ± 162) ng / L, P <0.01] ± 1 355) ng / L, P <0.01]. Serum HGF concentration in the left ventricular remodeling group was significantly higher than that in the non-left ventricular remodeling group on the 7th day of onset [(2 216 ± 1 522) ng / L vs (1 176 ± 593) ng / L, P <0.05] Admission concentration was no significant difference between the two groups. CONCLUSION: Serum HGF concentration increases at AMI, and elevated serum HGF at 7 d after AMI may predict ventricular remodeling.