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本文叙述了含硫碱基DNA的化学和医疗应用。硫碱基(thio-base)有其独特的性质,比如,易烷基化,易氧化和强的紫外长波(315—400nm,UVA)吸收。这些特定化学和物理性质存于含硫碱基、含硫核苷和含硫碱基的DNA中,它们对制备修饰的DNA和含硫碱基的DNA与其他生物大分子之间进行光诱导的交联反应非常有用。功能化的含有硫碱基的DNA及其类似物可用于DNA的修复研究。本文介绍和评述了利用紫外光/含硫胸腺嘧啶脱氧核苷(UVA/thiothymidine)的抗癌疗法,同时,探讨了含硫核苷类似物和紫外光之间的协同作用,为癌症和其他疾病治疗提供一种新的方法。
This article describes the chemical and medical applications of sulfur-based DNA. Thio-bases have their own unique properties such as readily alkylated, readily oxidizable and strong ultraviolet long wavelength (315-400 nm, UVA) absorption. These specific chemical and physical properties reside in DNA containing sulfur bases, sulfur containing nucleosides and sulfur bases, which light-induce between the preparation of modified DNA and the sulfur base-containing DNA and other biological macromolecules Cross-linking reaction is very useful. Functionalized sulfur base-containing DNA and its analogs can be used for DNA repair studies. This article describes and reviews the use of UVA / thiothymidine anticancer therapies, and explores the synergy between sulfur-containing nucleoside analogs and UV light for cancer and other diseases Treatment provides a new way.