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Objective To study the antagonism of polysaccharides from Dicliptera chinensis (L.) Nees towards hepatic fibrosis induced by dimethylnitrosamine (DMN) in Wistar rats.Methods The antagonism of polysaccharides from D.chinensis towards hepatic fibrosis was studied by exploring their effects on ALT,AST,TBIL and ALB contents of blood serum,liver wet weight and spleen wet weight in DMN-induced Wistar rats.The formation of hepatic fibrosis (HF) was observed with the help of Masson dyeing.Results The ALT,AST,TBIL and ALB contents of blood serum were significantly lower in highand low-dose groups of polysaccharides from D.chinensis than in model group,but by contrast the ALB content of blood serum in highand low-dose groups was higher than that in model group.The liver wet weight and spleen wet weight of rats in medication groups were obviously declined compared with model group.The polysaccharides from D.chinensis could significantly alleviate the inflammation,necrosis and fibrosis degree of liver.Conclusion The polysaccharides from D.chinensis have an antagonism towards hepatic fibrosis induced by DMN in Wistar rats,which may be associated with protecting liver and lowering transaminase.