众所周知,在口腔中糖发酵产酸是龋病发生的原因之一,但有的人虽吃糖却不发生龋齿,他们对龋病有自然免疫的能力。早在50年代初期就有人提出唾液中存在着使酸(包括丙酮酸,乙酸和乳酸)氧化的酶系统,并指出这些酶的来源是口腔中的细菌,这个酶系统是自然免疫的重要因素。后来,Bibby发现用 It is known to all that one of the reasons why cariogenic acidosis is produced by sugar fermentation in the oral cavity is that although some people eat sugar but do not have dental caries, they naturally have immunity to caries. As early as the early 1950s, it was suggested that there are enzyme systems in saliva that oxidize acids (including pyruvate, acetate and lactate) and indicate that the source of these enzymes is the bacteria in the mouth. This enzyme system is an important factor in innate immunity. Later, Bibby found out