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目的观察壮骨康齿胶囊对大鼠雌二醇含量及牙周组织发育的影响。方法选用40只雌性大鼠随机分成两组 ,每组20只 ,用药组每日灌胃壮骨康齿胶囊配制的药液1ml(含药量30mg) ,对照组每日灌胃蒸馏水1ml,连续30天后 ,取血测定两组大鼠雌二醇含量 ,解剖子宫卵巢称重 ,计算子宫重量指数 ;选择32只雌性大鼠分两组 ,每组16只 ,喂药方法同前 ,分别于第1、4、8、12周处死大鼠 ,取下颌前牙的牙周组织作组织学切片 ,光镜观察。结果实验用药组雌二醇含量、子宫卵巢重量 ,子宫重量指数均明显高于对照组(P<0.01);用药组牙龈上皮、牙周膜明显增厚 ,肌纤维明显增粗。结论壮骨康齿胶囊可以明显提高大鼠雌二醇含量 ,促进牙周组织的发育
Objective To observe the effect of Zhuanggu Kangzhi Capsule on estradiol content and periodontal development in rats. Methods Forty female rats were randomly divided into two groups with 20 rats in each group. The drug group was treated with Zhuanggu Kangto Capsule 1 ml (30mg), and the control group was given distilled water 1ml daily. After 30 days, blood was taken to determine the estradiol content in the two groups. The uterine ovary was dissected to calculate the uterine weight index. 32 female rats were divided into two groups with 16 rats in each group. 1, 4, 8 and 12 weeks after the rats were killed, the periodontal tissues of the mandibular anterior teeth were taken for histological section and observed under light microscope. Results The estradiol content, uterine ovary weight and uterine weight index of the experimental drug group were significantly higher than those of the control group (P<0.01). The gingival epithelium and periodontal ligament of the drug treatment group were significantly thickened, and the muscle fibers were significantly thickened. Conclusion Zhuanggukang Decoction can significantly increase the content of estradiol in rats and promote the development of periodontal tissues.