信号转导是细胞对各种外界刺激的应答反应,蛋白磷酸化或去磷酸化是信号从胞外流向胞内并导致细胞效应过程中的关键机制。磷酸化蛋白质组学(phosphoproteomics)是采用蛋白质组学的分析方法,研究细胞中所有磷酸化蛋白质及其修饰过程,从整体上观察细胞中被修饰的磷酸化蛋白质的状态及其变化,进而分析特定磷酸化修饰对生命过程的调控作用及其分子机制。 Signal transduction is the response of cells to various external stimuli. Phosphorylation or dephosphorylation of proteins is a key mechanism in the process of signal flow from the extracellular to intracellular and cellular effects. Phosphoproteomics is the use of proteomics analysis of all phosphorylated proteins in the cell and its modification process, the overall observation of the cells modified phosphorylation protein status and its changes, and then analyze the specific Regulation of Phosphorylation on Life Process and Its Molecular Mechanism.