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子宫内膜息肉(EP)可导致子宫不规则出血、不孕等,治疗后容易复发且有一定的恶变率,其发病机制尚不清楚。C-erbB-2癌蛋白是主要的表皮生长因子受体家族成员,与配体结合后胞内去酪氨酸自身磷酸化而具有激酶活性。其产物p185neu的外部生长因子或配体靠磷酸化或去磷酸化影响一系列跨膜蛋白和细胞内的信号转导,从而影响各种基因的转录,对肿瘤的发展起重要的生物学作用。C-erbB-2在EP中的表达可能为EP的研究和治疗提供了新的突破点。
Endometrial polyps (EP) can lead to irregular uterine bleeding, infertility, relapse after treatment and a certain degree of malignancy, the pathogenesis is not yet clear. The C-erbB-2 oncoprotein is a major member of the epidermal growth factor receptor family and binds to ligands to de-tyrosine autophosphorylation with kinase activity. Its product p185neu’s external growth factor or ligand by phosphorylation or dephosphorylation affect a series of transmembrane proteins and intracellular signal transduction, thus affecting the transcription of various genes, the tumor plays an important biological role. The expression of C-erbB-2 in EP may provide a new breakthrough point for the research and treatment of EP.