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2012年11月,国家食品药物监督管理局(SFDA)发布第51期药物不良反应信息通报,提醒医务人员和患者警惕他汀类药物血糖异常不良反应及与HIV(人类免疫缺陷病毒)蛋白酶抑制剂的相互作用。研究发现,他汀类药物可引起患者血糖异常,表现为空腹血糖、糖化血红蛋白水平升高,新发糖尿病,糖尿病血糖控制恶化等;此外,他汀类药物与HIV蛋白酶抑制剂同时服用,可能会使他汀类药物的血药浓度增高,增加包括横纹肌溶解在内的严重不良反应发生的风险。
In November 2012, the SFDA released the 51st ADR, alerting medical staff and patients on vigorous glycemic excretion of statins and their association with HIV (human immunodeficiency virus) protease inhibitors interaction. The study found that statins can cause patients with abnormal blood glucose, manifested as fasting blood glucose, glycosylated hemoglobin levels, new onset of diabetes, diabetes, blood glucose control deterioration; In addition, statins and HIV protease inhibitors taken at the same time, may make statin The increased plasma concentration of drugs increases the risk of serious adverse reactions, including rhabdomyolysis.