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目的 :比较阿替洛尔片和地尔硫缓释胶囊治疗轻中度高血压患者的血压、心率和生活质量的影响。方法 :73例轻中度原发性高血压 (舒张压 90～ 10 9mm Hg)患者被随机分 2组 ,分别服用阿替洛尔片 2 5 mg/ d(A组 ,n= 37)和地尔硫缓释胶囊 90 mg/ d(B组 ,n=36 )。比较治疗前及治疗 8周后对心率、诊所血压 (OBP)、动态血压(ABP)和生活质量的影响。结果 :服药 8周后 A组和 B组心率分别下降 (11.2± 12 .4 )次 / min和 (8.8± 6 .3)次 /min,OBP分别下降 (2 1.1± 10 .0 / 19.1± 7.6 ) mm Hg和 (2 8.1± 10 .4 / 2 0 .7± 6 .7) mm Hg,A组和 B组降压有效率分别为 88.2 %和 93.8%。A、B两组 ABP日间平均收缩压和舒张压分别下降 (10 .3± 14 .2 / 6 .2± 8.5 ) mm Hg和 (8.1± 12 .4 / 6 .9± 7.9) mm Hg,夜间平均收缩压和舒张压分别下降 (9.4± 14 .3/ 5 .9± 10 .5 ) mm Hg和 (6 .8± 11.0 / 5 .4±8.1) mm Hg,组内治疗前后比较差异有显著性 (P<0 .0 5～ 0 .0 1)。服药 8周后两组在躯体健康、心理健康和社会功能方面均有不同程度的改善 ,组内比较示 B组躯体健康改善有统计学意义 (P<0 .0 5 )。A组和 B组不良反应发生率分别为 2 1.6 %和 11.1%。结论 :阿替洛尔和地尔硫均有较好的降压作用 ;阿替洛尔减慢心率?
Objective: To compare the effects of atenolol tablets and diltiazem tablets on blood pressure, heart rate and quality of life in patients with mild to moderate hypertension. Methods: A total of 73 patients with mild to moderate essential hypertension (diastolic blood pressure 90 to 109 mm Hg) were randomly divided into two groups, taking atenolol tablets 25 mg / d (group A, n = 37) Sulfuricotin Sustained Release Capsules 90 mg / d (Group B, n = 36). The effects of heart rate, clinic blood pressure (OBP), ambulatory blood pressure (ABP) and quality of life before and 8 weeks after treatment were compared. Results: The heart rate of group A and group B decreased (11.2 ± 12.4) times / min and (8.8 ± 6.3) times / min respectively after 8 weeks’ medication, and OBP decreased (2 1.1 ± 10 .0 / 19.1 ± 7.6 ) mm Hg and (2 8.1 ± 10 .4 / 2 0 .7 ± 6 .7) mm Hg respectively. The effective rates of lowering blood pressure in group A and group B were 88.2% and 93.8%, respectively. Mean daytime systolic and diastolic blood pressure (ABP) of ABP in group A and group B decreased by (10.3 ± 14.2 / 6.2 ± 8.5) mm Hg and (8.1 ± 12.4 / 6.9 ± 7.9) mm Hg respectively, Mean systolic and diastolic blood pressure decreased at night (9.4 ± 14.3 / 5 .9 ± 10 .5) mm Hg and (6.8 ± 11.0 / 5 .4 ± 8.1) mm Hg, respectively Significance (P <0. 05 ~ 0. 01). After 8 weeks of taking the medicine, the two groups had different degrees of improvement in physical health, mental health and social function. The comparison of the two groups showed that the improvement of physical health in group B was statistically significant (P <0.05). The incidence of adverse reactions in groups A and B were 21.6% and 11.1%, respectively. Conclusion: Atenolol and diltiazem have a better antihypertensive effect; atenolol slows the heart rate?