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目的:探讨载脂蛋白B(ApoB)/载脂蛋白A1(ApoA1)比值与胰岛素抵抗(Insulin Resistance,IR)的关系。方法:纳入673例重庆地区成年人,测定体重、身高、血压、腰围、空腹血浆葡萄糖(Fastingplasma glucose,FPG)、空腹血清胰岛素(Fasting serum insulin,FINS)及血脂等,计算ApoB/ApoA1比值、体重指数(Bodymassindex,BMI)及胰岛素抵抗指数(Homa-IR)。根据ApoB/ApoA1的四分位值将人群分为4组,用Logistic回归分析ApoB/ApoA1值与IR的关系。结果:与非胰岛素抵抗(Non-insulinresistance)者相比,IR人群的年龄、BMI、收缩压、舒张压、FPG、FINS、TG、LDL-c水平及ApoB/ApoA1比值均显著增高,而HDL-c水平降低(P<0.05);随ApoB/ApoA1值增高,HomaIR值逐渐增高(P<0.001);ApoB/ApoA1值最高组(上四分位组)发生IR的风险是最低组(下四分位组)的2.586倍(P=0.001)。结论:ApoB/ApoA1比值与IR密切相关,ApoB/ApoA1比值增高是IR发生的重要标志。
Objective: To investigate the relationship between ApoB / ApoA1 ratio and Insulin Resistance (IR). Methods: A total of 673 adults in Chongqing were enrolled in this study. Body weight, height, blood pressure, waist circumference, fasting plasma glucose (FPG), fasting serum insulin (FINS) and serum lipids were measured to calculate the ApoB / ApoA1 ratio Body mass index (BMI) and insulin resistance index (Homa-IR). According to the quartiles of ApoB / ApoA1, the population was divided into 4 groups. Logistic regression was used to analyze the relationship between ApoB / ApoA1 and IR. Results: The age, BMI, systolic blood pressure, diastolic blood pressure, FPG, FINS, TG, LDL-c and the ratio of ApoB / ApoA1 in IR population were significantly higher than those in non-insulin resistance group (P <0.001). The risk of IR in the highest ApoB / ApoA1 group (upper quartile) was the lowest (lower quartile) (P <0.05). The higher the ApoB / ApoA1 value, the higher the HomaIR value Bit group) 2.586 times (P = 0.001). Conclusion: The ApoB / ApoA1 ratio is closely related to IR. The increased ApoB / ApoA1 ratio is an important marker of IR.