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在过去的10几年里,已经认识到一氧化氮在正常的生理和病理生理过程中有着重要的作用。一氧化氮是由细胞内一氧化氮合酶合成的,在正常生理状态下是调节血管舒缩活性的重要物质．非对称二甲基精氨酸是内源性一氧化氮合酶的竞争性抑制剂。近年来发现高血压患者血浆二甲基精氮酸水平升高,且血浆二甲基精氨酸浓度与内皮功能失调及动脉粥样硬化的严重程度有关．因此认为,二甲基精氨酸是一类新的血管疾病的危险因素．
In the past 10 years, it has been recognized that nitric oxide plays an important role in normal physiological and pathophysiological processes. Nitric oxide is synthesized by intracellular nitric oxide synthase and is an important substance that regulates vasomotor activity under normal physiological conditions. Asymmetric dimethyl arginine is a competitive inhibitor of endogenous nitric oxide synthase. In recent years, patients with hypertension found that plasma dimethylolinic acid levels, and plasma concentrations of dimethyl arginine and endothelial dysfunction and the severity of atherosclerosis. Therefore, dimethyl arginine is a new type of vascular disease risk factors.