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目的:研究鱼腥草及新鱼腥草素钠2种注射剂在大鼠体内的代谢规律。方法:采用GC-MS测定大鼠静脉注射及口服鱼腥草(多成分)及新鱼腥草素钠(单成分)2种注射剂血浆和尿液中代谢产物,验证“网通性”代谢规律。结果:大鼠分别静注鱼腥草和新鱼腥草素钠注射剂后,血浆中检测出8种共同代谢产物,而尿液中检出39种;口服给药后,血浆中检测出16种共同代谢产物,而尿液中检出12种。鱼腥草注射剂经静注和口服2种不同给药形式后,血浆和尿液中分别检测出9和11种共同代谢产物,而新鱼腥草素钠注射剂分别检出8和17种。结论:鱼腥草及新鱼腥草素钠2种注射剂静注与口服后,在大鼠体内的代谢产物相同或相似,与原制剂挥发油成分结构类型相同,代谢途径相同。中药成分在生物体内代谢存在“网通性”。
Objective: To study the metabolism of Houttuynia cordata Thunb and sodium houttuyfonate 2 in rats. Methods: The plasma and urine metabolites of two injections of Houttuynia cordata (multiple components) and sodium houttuyfonate (single component) were intravenously injected into the rat by GC-MS, and the metabolites law. Results: After intravenous injection of Houttuynia Cordata Thunb and sodium houttuyfonate injection, 8 common metabolites were detected in plasma and 39 in urine. After oral administration, 16 Metabolites, while 12 were detected in urine. Houttuynia injection after intravenous and oral administration of two different forms, respectively, 9 and 11 kinds of co-metabolites were detected in plasma and urine, and new sodium houttuyfonate injection were detected in 8 and 17 species. Conclusion: Houttuynia Cordata and sodium houttuyfonate two kinds of injection after intravenous and oral administration, the metabolites in rats the same or similar to the original formulation of volatile oil components of the same type of structure, the same metabolic pathway. Chinese medicine metabolism in the body there is “Netcom ”.