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目的:总结国内外对血管内皮生长因子C(VEGF-C)的结构、功能以及在喉癌组织中的表达及临床意义的研究进展。方法:应用检索中国数字图书馆、维普及Medline数据库,以“VEGF-C、喉癌”等为关键词,检索2000-01-2009-09的相关文献,共检索到中文76篇,英文121篇。纳入标准:1)VEGF-C的结构、功能的研究。2)VEGF-C在喉癌组织中的表达及临床意义的研究。根据纳入标准,最后纳入分析24篇文献。结果:VEGF-C是血管内皮生长因子家族的一员,它与VEGF-A高度同源,主要作用是与相应的VEGF-R3结合介导淋巴管的增生,包括管径的增加和数量的增加。VEGF-C可选择性的表达于喉癌细胞,并与肿瘤的淋巴结转移及分化程度密切相关,而与患者的年龄、性别、病变部位及T分期无关。结论:关于VEGF-C的研究目前仍处于起步阶段,其在促进喉癌的发生及淋巴结转移中的作用机制以及VEGF-C抑制剂等还需进一步研究。随着研究的不断深入,将会给喉癌的诊断、治疗开辟一条新的途径。
OBJECTIVE: To summarize the research progress at home and abroad on the structure and function of vascular endothelial growth factor C (VEGF-C) and its expression in laryngeal squamous cell carcinoma and its clinical significance. Methods: The relevant literature of 2000-01-2009-09 was retrieved by searching “China Digital Library, VIP and Medline database” with “VEGF-C, laryngeal cancer” as the key words, 76 Chinese were retrieved 121 articles. Inclusion criteria: 1) Study on the structure and function of VEGF-C. 2) VEGF-C in laryngeal squamous cell carcinoma and its clinical significance. According to the inclusion criteria, finally included in the analysis of 24 documents. Results: VEGF-C is a member of the vascular endothelial growth factor family. It is highly homologous to VEGF-A. The main role of VEGF-C is to bind with the corresponding VEGF-R3 to mediate the proliferation of lymphatic vessels, including the increase of the diameter and the increase of the number . VEGF-C is selectively expressed in laryngeal cancer cells and is closely related to the degree of lymph node metastasis and differentiation of the tumor, regardless of the patient’s age, sex, lesion location and T stage. Conclusion: The research on VEGF-C is still in its infancy, and its role in promoting the occurrence of laryngeal cancer and lymph node metastasis and VEGF-C inhibitors need further study. With the deepening of the research, it will open up a new way for the diagnosis and treatment of laryngeal cancer.