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目的观察GFAP和CD44v6在腺样囊性癌中的表达,探讨其与腺样囊性癌嗜神经侵袭间的关系。方法选取31例腺样囊性癌以及正常腮腺组织和神经鞘瘤组织,进行CD44v6和GFAP免疫组织化学染色。结果有20例出现瘤细胞包绕神经现象,11例无神经包绕现象,前者20例均GFAP有阳性表达(100%);后者只有2例(18.18%)阳性表达。阳性细胞分布于肿瘤细胞团中或环形分布于筛孔状结构的周边。两组间GFAP阳性率比较,P<0.01。而CD44v6出现瘤细胞包绕神经现象的腺样囊性癌的阳性率为85%(17/20),在无神经包绕现象的腺样囊性癌阳性率为45.46%(5/11)阳性表达,P<0.01。结论GFAP和CD44v6不仅与腺样囊性癌“嗜神经侵袭”有关,而且CD44v6也可能为腺样囊性癌的发生、发展的组织学因素之一。
Objective To observe the expression of GFAP and CD44v6 in adenoid cystic carcinoma and to explore their relationship with the invasion of adenoid cystic carcinoma. Methods Seventy adenoid cystic carcinomas, as well as normal parotid gland and schwannoma were selected for immunohistochemical staining of CD44v6 and GFAP. Results There were 20 cases of neoplasia around the nerve cells and 11 cases of no nerve entrapment. The former had positive expression of GFAP in all 20 cases (100%), and the latter 2 cases (18.18%). Positive cells distributed in the tumor cell mass or ring-shaped distribution around the sieve-like structure. GFAP positive rate between the two groups, P <0.01. However, the positive rate of adenoid cystic carcinoma with CD44v6 neoplasia was 85% (17/20). The positive rate of adenoid cystic carcinoma without neoplasia was 45.46% (5/11) Expression, P <0.01. Conclusion GFAP and CD44v6 are not only associated with adenoid cystic carcinoma, but also CD44v6 may be one of the histological factors in the development of adenoid cystic carcinoma.