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作者采用高效液相色谱法对１０例可切除进展期胃癌进行腹腔卡铂术前化疗药代动力学研究。卡铂３００ｍｇ／ｍ２加生理盐水７５０ｍｌ快速腹腔注射，１６０～１８０ｍｉｎ取腹腔液、门静脉及外周血，２４０～２７０ｍｉｎ取癌组织、癌旁正常组织、腹膜、大网膜、阴性淋巴结，测定总铂浓度。结果表明，腹腔液浓度最高，平均４８．１４μｌ／ｍｌ，门静脉次之为１０．１μｌ／ｍｌ，分别是外周血的８、１．６倍。被测组织中，腹膜浓度超出其它组织浓度（Ρ＜０．０５），癌组织含量高于正常组织。研究证明，卡铂术前腹腔化疗不仅提高腹腔、门静脉药物浓度，而且，在腹膜、癌组织内有一定聚积性，对于杀灭腹腔亚临床病灶，改善临床分期，控制医源性转移，提高治愈性手术切除率发挥重要作用。
The authors used high performance liquid chromatography in 10 cases of resectable advanced gastric cancer preoperative cardiotoxicity pharmacokinetic study. Carboplatin 300mg / m2 plus saline 750ml fast intraperitoneal injection, 160 ~ 180min peritoneal fluid, portal vein and peripheral blood, 240 ~ 270min take cancer tissue, adjacent normal tissue, peritoneum, omentum, negative lymph nodes, determination of total platinum concentration . The results showed that the highest peritoneal fluid concentration, an average of 48.14μl / ml, portal vein followed by 10.1μl / ml, respectively, 8,1.6 times the peripheral blood. The measured tissue, peritoneal concentration than other tissue concentrations (P <0.05), cancer tissue content higher than normal tissue. Studies have shown that carboplatin preoperative intraperitoneal chemotherapy not only improve the abdominal cavity, portal vein drug concentration, and, in the peritoneum, cancer tissue has a certain accumulation, for the destruction of subclinical abdominal lesions, improve clinical staging, control of iatrogenic metastasis and improve healing Sexual resection rate plays an important role.