前列腺特异性抗原 (prostatespecificantigen ,PSA)是目前广泛应用的前列腺癌 (Pca)肿瘤标记物。但深入研究表明PSA还不是早期检测Pca的理想瘤标 ,它还缺乏足够的敏感性和特异性 ,这是因为PSA是前列腺特异而非Pca特异。为增加PSA早期诊断Pca的特异性和敏感性 ,近年提出了PSA密 Prostate-specific antigen (PSA) is a widely used prostate cancer (Pca) tumor marker. However, in-depth studies have shown that PSA is not an ideal tumor marker for early detection of Pca. It lacks adequate sensitivity and specificity because PSA is prostate specific rather than Pca specific. In order to increase the specificity and sensitivity of early diagnosis of Pca in PSA, PSA density has been proposed in recent years