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目的 通过Ualcan数据库探讨caspase-7(CASP7)在结肠癌中的表达和意义.方法 统计Ualcan数据库中CASP7在结肠癌中的表达情况并进行生存分析,通过Oncolnc数据库对得出的结果进行验证.并分析CASP7与KRAS 基因和TP53I3基因的协同表达情况.结果 在结肠癌中,CASP7的表达较低,且低表达者的预后劣于高表达者.CASP7与KRAS基因和TP53I3基因存在共表达.结论 CASP7在结肠癌中存在低表达且与不良预后相关.“,”Objective To discuss the expression of caspase-7 (CASP7) and its prognostic role in colon cancer. Methods CASP7 expression data was retrieved from Ualcan database, and the survival data of CASP7 down-regulated colon cancer patients was retrieved from Ualcan database and Oncolnc database. Results In colon cancer, the expression of CASP7 was down-regulated and indicated a relatively worse prognosis. The expression of CASP7 was correlated with KRAS and TP53I3. Conclusions CASP7 is down-regulated in colon cancer and indicates a worse prognosis.