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目的:了解广东省人群各种乙肝病毒感染模式的发生情况及其与年龄、性别和城乡的关系。方法:采取多阶段随机抽样的方法,抽取广东省的6个县区3925人为研究对象,进行问卷调查和乙肝病毒血清学指标检测。结果:广东省人群乙肝病毒感染模式共有11种,常见模式6种,发生率从高到低依次为:模式“2”(40.36%)、五项全阴模式(22.73%)、“25”(22.29%)、“145”(6.65%)、“135”(4.23%)和“5”(3.52%)。随着年龄增大,模式“145”、“5”、“25”发生率升高,模式“2”的发生率下降,差异有显著性;5~14岁人群五项全阴模式的发生率最高。男性模式“2”的发生率显著高于女性,但模式“25”的发生率显著低于女性。城市人群模式“145”、“135”和“5”的发生率均显著低于农村人群,但模式“2”和五项全阴模式的发生率显著高于农村人群。结论:广东省人群乙肝病毒感染模式与同时期其他地区相比,单独HBsAb阳性等恢复期模式发生率较高,“大三阳”和“小三阳”等感染期模式发生率较低,说明广东省的预防接种工作开展良好,人群免疫水平较高。
Objective: To understand the patterns of hepatitis B virus infection in Guangdong population and its relationship with age, gender, urban and rural areas. Methods: A total of 3925 people from 6 districts and counties of Guangdong Province were selected as the research object by multi-stage random sampling method, and questionnaires and serological indexes of hepatitis B virus were detected. Results: There were 11 hepatitis B virus (HBV) infection patterns in Guangdong population and 6 common patterns. The incidence rate was from high to low in the order of 40.36% in pattern, 22.73% in all five patterns, 25%, 145%, 135%, and 5%. With the increase of age, the incidence of patterns “145”, “5”, “” 25 “increased and the incidence of pattern” 2 “decreased with significant difference; Five full negative mode the highest incidence. The incidence of male pattern ”2“ was significantly higher than that of female, but the incidence of pattern ”25“ was significantly lower than that of female. The incidence of urban population pattern 145, 135 and 5 was significantly lower than that of rural population, but the incidence of patterns 2 and all five patterns was significantly higher than that of rural areas crowd. Conclusion: Compared with other regions in the same period, the prevalence of HBsAb-positive recovery convalescence mode is higher in Guangdong population than in other regions of the same period. The prevalence of infection mode such as ”Sanshengyang“ and ”Xiaosanyangyang" Low, indicating that the vaccination work in Guangdong Province carried out well, a higher level of population immunity.