颅内入路适用于鞍上的较大型肿瘤,但不适用于鞍内肿瘤。当肿瘤有分泌功能时则需要将腺瘤组织完全切除才能获得较好的效果,同时经额入路对于鞍内异常组织的直接显露受到限制,势必促使外科医师较盲目地将整个脑垂体切除,造成无垂体功能的不良后果。因此所有病人术后都要长期用可地松和甲状腺素治疗。二十世纪初期,欧州鼻科学者曾设想通过鼻腔和蝶窦进入蝶鞍切除鞍内肿瘤,1907年 Schloffer 曾切开外鼻除去鼻甲和 Intracranial approach is suitable for larger tumors on the saddle, but not for intra-sellar tumors. When the tumor has secretory function, the adenoma tissue needs to be completely resected in order to obtain a better effect. Meanwhile, the direct exposure of the abnormal tissue in the saddle through the frontal approach is limited, which will inevitably prompt surgeons to blindly remove the entire pituitary gland, Caused by the negative consequences of pituitary function. Therefore, all patients should be long-term use of cortisone and thyroxine treatment. Early twentieth century, the European nasal scientists had envisaged to enter the sella by intranasal and sphenoid sinus resection of the saddle tumor, Schloffer had cut the nasal debridement in 1907 and