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目的：了解青蒿酯钠的抗肿瘤作用。方法：用青蒿酯钠在体内、外进行抗肿瘤实验，通过伊红染色法检测青蒿酯钠对体外培养人宫颈癌（ＨｅＬａ）细胞杀伤作用。用ＭＴＴ法检测青蒿酯钠对体外培养人低分化鳞状上皮鼻咽癌（ＣＮＥ２及ＳＵＮＥ－１）细胞杀伤作用。结果：体外实验表明青蒿酯钠对３种细胞均有杀伤作用，ＩＣ５０分别为４２．７μｇ／ｍｌ、１０１．６μｇ／ｍｌ、１．２９μｇ／ｍｌ。体内实验表明在５０ｍｇ／ｋｇ·ｄ和１００ｍｇ／ｋｇ·ｄ的剂量下静脉给药对Ｓ－１８０、肝癌及ＬⅡ抑瘤率分别为２４～５３％、２１～４９％及４２～５８％；在１５０ｍｇ／ｋｇ·ｄ和３００ｍｇ／ｋｇ·ｄ剂量下灌胃给药对ＬⅡ和裸鼠移植人鼻咽癌（ＣＮＥ２及ＳＵＮＥ－１）抑瘤率分别为４２．４～７１．４％、２５～４２％及３０～５０％；但对荷艾氏腹水瘤和白血病Ｌ６１５小鼠没有延长生存期作用。结论：青蒿酯钠有抗肿瘤作用。
Objective: To understand the antitumor effect of sodium artesunate. Methods: Antitumor experiments were conducted with artesunate sodium in vitro and in vivo. The killing effect of artesunate sodium on human cervical carcinoma HeLa cells was detected by eosin staining. The killing effect of artesunate sodium on human poorly differentiated squamous cell carcinoma of nasopharyngeal carcinoma (CNE2 and SUNE-1) cells in vitro was detected by MTT assay. Results: In vitro experiments showed that artesunate sodium had cytotoxicity on all three kinds of cells with IC50 of 42.7μg / ml, 101.6μg / ml and 1.29μg / ml, respectively. In vivo experiments showed that the tumor inhibition rates of S-180, HCC and LII were 24-53%, 21-49% and 42-58% at the doses of 50mg / kg · d and 100mg / kg · d, respectively. The inhibitory rates of oral administration of 150mg / kg · d and 300mg / kg · d were 42.4 ~ 71.4%, 42 ~ 71.4% respectively in LⅡ and nude mice transplanted human nasopharyngeal carcinoma (CNE2 and SUNE-1) 42%, and 30% -50%, respectively; however, no effect on survival was observed in Heterocystoma and Leukemia L615 mice. Conclusion: Artesunate sodium has anti-tumor effect.