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目的:通过了解阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者UPPP前后尿尿酸/尿肌酐(UA/Cr)的变化,以判断UPPP的治疗价值。方法:患者35例,于晚间留取第1份尿液标本后进行PSG的测定;次日晨6h左右留取第2份标本,测定UA、Cr。AHI≥5者23例,为OSAHS组;从中选适合手术的OSAHS患者15例进行UPPP治疗,为治疗组;AHI<5者12例为对照组。结果:OSAHS组AHI明显高于对照组(t=23.95,P<0.01),治疗后比治疗前明显下降(t=6.53,P<0.01);OSAHS组尿(UA/Cr)明显高于对照组(P<0.05),治疗后比治疗前明显下降(P<0.01)。尿(UA/Cr)与AHI无相关性。结论:尿(UA/Cr)仅能反映UPPP治疗后对机体缺氧的纠正程度,对于同一患者用该项指标来作为随访观察UPPP的治疗效果有一定的实用价值。
OBJECTIVE: To investigate the changes of uric acid / creatinine (UA / Cr) before and after UPPP in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) to determine the therapeutic value of UPPP. Methods: 35 patients were enrolled, and the first urine samples were collected for determination of PSG at night. The second specimen was collected at about 6h the next morning for UA and Cr determination. Fifteen patients with AHI≥5 were OSAHS group. Fifteen patients with OSAHS who underwent surgical treatment were enrolled in the UPPP treatment group, and 12 patients with AHI <5 as control group. Results: The AHI in OSAHS group was significantly higher than that in control group (t = 23.95, P <0.01), and the level of AHI in OSAHS group was significantly lower than that before treatment (t = 6.53, (P <0.05), but decreased significantly after treatment (P <0.01). Urine (UA / Cr) and AHI no correlation. Conclusion: Urine (UA / Cr) can only reflect the degree of correction of hypoxia after UPPP treatment. It is of practical value to observe the effect of UPPP in this same patient by follow-up.