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本文报告了38例服醋炔诺酮肟避孕片(其中26例服探亲片、12例服事后片)和3例不服药的健康妇女的子宫内膜活检结果及11名服酮肟探亲片妇女12个周期的阴道细胞学观察结果。所有服药妇女的子宫内膜发育均受不同程度抑制,对在周期早期开始服药者内膜的抑制作用较后期服药者明显。表明药物干扰了内膜的发育和分泌,这可能是该药避孕作用的主要机理。阴道细胞学检查表明,服药后阴道细胞因保持较低的雌激素影响而缺乏正常的周期变化,提示在周期的早期开始服药可能抑制排卵。
This article reports the results of endometrial biopsy of 38 patients receiving prophylactic ketoconazole (26 inoculated and 12 in service) and 3 healthy women without medication, and 11 women 12 cycles of vaginal cytology results. All taking women’s endometrial development were inhibited to varying degrees, the beginning of the cycle began to take medication intima more effective than the late medication. Indicating that drugs interfere with the development and secretion of the endometrium, which may be the main mechanism of the contraceptive effect of the drug. Vaginal cytology tests showed that vaginal cells lacked normal cycle changes due to lower estrogen levels after taking the drug, suggesting that taking the drug early in the cycle may suppress ovulation.