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单核细胞趋化因子蛋白-1（ MCP-1）是由多种细胞分泌的一种CC类趋化因子，在人体内发挥趋化性、吞噬性和促进炎性因子合成等多种作用。 MCP-1参与并促进糖尿病血管并发症的发生和发展。本文概述了MCP-1的分子结构、生物学功能、影响因素及其与相关疾病的关系，特别是与动脉粥样硬化、冠心病、糖尿病肾病、糖尿病视网膜病变、糖尿病性心肌病以及糖尿病足病之间相互关系的研究进展。“,”Monocyte chemoattractant protein 1 ( MCP-1) is a CC chemokines secreted by many types of cells , in the human body play a variety of roles like chemotaxis , phagocytosis and synthesis of inflammatory mediators .MCP-1 participated and promoted occurrence and development of diabetic vascular complications .This paper summarized the structure , function and influencing factor of MCP-1, as well as the relationship between MCP-1 and related diseases , especially the progress in the field it and atherosclerosis and coronary heart disease , as well as MCP-1 and diabetic nephropathy and diabetic retinopathy and diabetic cardiomyopathy and diabetic foot .