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作者用碱性磷酸酶抗碱性磷酸酶(APAAP)免疫组化法研究19例桥本甲状腺炎(HT)。11例Graves病(GD)和4例非毒性甲状腺肿(NTG)的甲状腺滤泡细胞(TFC)HLA-DR抗原的异常表达。发现TFC DR抗原表达与自身抗体值无明确相关性,而与甲状腺中淋巴细胞浸润程度密切相关,与浸润淋巴细胞的DR抗原表达相关更密切。提示活化T细胞能促进TFC DR抗原的表达.在HT,TFCDR抗原的表达强于OD和NTG。
The authors used alkaline phosphatase anti-alkaline phosphatase (APAAP) immunohistochemical study of 19 cases of Hashimoto’s thyroiditis (HT). 11 cases of Graves disease (GD) and 4 cases of non-toxic goiter (NTG) thyroid follicular cells (TFC) HLA-DR antigen abnormal expression. TFC DR antigen expression was found no significant correlation with the value of autoantibodies, but closely related to the degree of lymphocytic infiltration in the thyroid gland, and infiltrating lymphocytes more closely related to the expression of DR antigen. It is suggested that activated T cells promote the expression of TFC DR antigen, and the expression of TFCDR antigen is stronger than OD and NTG in HT.