借鉴文章实验证明川芎嗪对于小鼠的早期妊娠有一定的影响,对雄性小鼠也具有一定的生殖毒性,较长时间用药可以杀死精子,造成不育(与健康雌性小鼠自由交配不生育),但不影响雄性激素分泌,作为雄性避孕药使用有一定的优势。因此,本实验设计短期用药对小鼠精子活动率的影响及停药后的恢复情况,以观察川芎嗪对雄性的可能避孕作用。 Literazine has been used for experiments to show that ligustrazine has a certain influence on early pregnancy in mice and reproductive toxicity on male mice. The use of drugs can kill sperms for a long time and cause infertility (free mating with healthy female mice. ), but does not affect the secretion of male hormones and has certain advantages as a male contraceptive. Therefore, this experiment designed the effect of short-term medication on the sperm activity rate in mice and recovery after discontinuation to observe the possible contraceptive effect of tetramethylpyrazine on males.