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目的探讨糖尿病史、颈动脉狭窄与进展性缺血性卒中患者的相关性。方法选取我院收治的神经内科缺血性卒中患者385例,其中进展性缺血性卒中230例(进展组),非进展性缺血性卒中155例(非进展组),均行颈动脉超声检查及血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血清同型半胱氨酸(Hcy)、空腹血糖和糖化血红蛋白检测,并收集所有患者临床资料进行分析。结果高血压、糖尿病史、颈动脉狭窄、TC、TG、Hcy、糖化血红蛋白均为进展性缺血性卒中相关影响因素(P<0.05);经Logistic回归分析可知,糖尿病史为进展性缺血性卒中相关危险因素(P=0.016,OR=5.312,95%CI=1.124~10.317),颈动脉狭窄为进展性缺血性相关危险因素(P=0.029,OR=3.372,95%CI=1.039~10.125)。Spearman检验可知,糖尿病史、颈动脉狭窄与进展性缺血性卒中呈正相关关系(P<0.05)。结论糖尿病史、颈动脉狭窄均为进展性缺血性卒中相关危险因素,且糖尿病史、颈动脉狭窄与进展性缺血性卒中呈正相关,临床可通过观察患者糖尿病史及颈动脉狭窄发生率预测缺血性卒中发生、进展。
Objective To investigate the relationship between history of diabetes, carotid artery stenosis and patients with progressive ischemic stroke. Methods A total of 385 patients with ischemic stroke admitted to our hospital were enrolled, including 230 progressive ischemic stroke patients (progressive group) and 155 non-progressive ischemic stroke patients (non-progressive group). All patients underwent carotid ultrasonography (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), serum homocysteine (Hcy), fasting blood glucose and glycosylated hemoglobin All patients were collected for clinical data analysis. Results Hypertension, history of diabetes mellitus, carotid artery stenosis, TC, TG, Hcy and HbA1c were the influencing factors of progressive ischemic stroke (P <0.05). Logistic regression analysis showed that the history of diabetes was progressive ischemic (P = 0.016, OR = 5.312, 95% CI = 1.124-10.317), carotid artery stenosis was the risk factor associated with progressive ischemic stroke (P = 0.029, OR = 3.372, 95% CI = 1.039-10.1025 ). Spearman test shows that diabetes history, carotid stenosis and progressive ischemic stroke were positively correlated (P <0.05). Conclusions Diabetes mellitus and carotid artery stenosis are both risk factors associated with progressive ischemic stroke. Diabetes mellitus, carotid artery stenosis and progressive ischemic stroke are positively correlated. The prevalence of diabetes mellitus and carotid artery stenosis can be predicted clinically Ischemic stroke, progress.