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虽然服用普鲁卡因酰胺与引起粒细胞减少症的因果关系已有充分证据,然而单独引起血小板减少症还缺乏有力的证据。作者通过一患者的病程观察指出服用普鲁卡因酰胺确能引起血小板减少症。患者,81岁,高加索妇女,因突然发生瘀点而住院。2个半月前她被诊断患有特发性肥厚性主动脉瓣下狭窄(IHSS)和室性阵发性心动过速,安装心脏起搏器和服用硫酸奎尼丁均未能控制阵发性心动过速。两个月前开始应用普鲁卡因酰胺(3g/天)并停用硫酸奎尼丁。入院前两天发现瘀点遍及下肢,体检时发现上肢亦有数处瘀斑。血小板计数8000/mm~3,血红蛋白
Although the causal relationship between procainamide and neutropenia has been well documented, there is no strong evidence of thrombocytopenia alone. The authors through a patient’s course of observation pointed out that taking procainamide can indeed cause thrombocytopenia. Patient, 81-year-old, Caucasian woman hospitalized for sudden onset of petechia. She was diagnosed with idiopathic hypertrophic aortic subacular stenosis (IHSS) and ventricular tachycardia 2 and a half months ago. Both pacemakers and quinidine sulfate failed to control paroxysmal heartbeat Too fast. Procurene (3 g / day) was started two months ago and quinidine sulphate was discontinued. Two days before admission found that petechia covered the lower limbs, physical examination found that there are several upper extremities ecchymosis. Platelet count 8000 / mm ~ 3, hemoglobin